Vasili Hauryliuk
Principal Investigator
Senior lecturer Vasili Hauryliuk is research team manager of the Molecular Enzymology Group at the Department of Experimental Medical Science at Lund University. His research group works on structural and functional characterizing of molecular mechanisms of bacterial antiphage immunity.
Project in second call:
Molecular mechanisms of antiphage defense
Principal Investigator
Senior lecturer Vasili Hauryliuk is research team manager of the Molecular Enzymology Group at the Department of Experimental Medical Science at Lund University. His research group works on structural and functional characterizing of molecular mechanisms of bacterial antiphage immunity.
Project in second call:
Molecular mechanisms of antiphage defense
Principal Investigator
Senior lecturer Vasili Hauryliuk is research team manager of the Molecular Enzymology Group at the Department of Experimental Medical Science at Lund University. His research group works on structural and functional characterizing of molecular mechanisms of bacterial antiphage immunity.
Project in second call:
Molecular mechanisms of antiphage defense
Short Biography
Dr. Vasili Hauryliuk leads the Molecular Enzymology group at the Department of Experimental Medical Science at Lund University. The Hauryliuk lab uses a combination of microbiological, biochemical and structural approaches to study mechanisms of how bacteria defend against their viruses, bacteriophages.
Dr Hauryliuk obtained his PhD in 2008 at Uppsala University, Sweden. His scientific contributions were recognized though the Ragnar Söderberg fellowship in Medicine (2014), the Swedish Fernström Prize (Fernströmpriset) (2019) and Göran Gustafssonpriset (2024).
AMBER postdoctoral fellowship subject (second call)
Project 1: Molecular mechanisms of antiphage defense
Bacteria are constantly predated by viruses, bacteriophages. To resist predation, bacteria employ numerous antiphage defence systems, with the most famous being CRISPR-Cas. In our lab we discover new systems with bioinformatics, validate them in microbiological assays and then characterise the mechanisms of defence on the molecular level.
Currently the lab is working on many (>10) novel, as-yet-unpublished antiphage defence systems. The mechanisms of phage detection and restriction by these systems is currently unknown. The focus of this project would be to uncover their molecular workings through integrated structure-functional approach combining phage microbiology, biochemistry and structural biology.
The project is supervised by Vasili Hauryliuk (PI) as well as Gemma Atkinson (co-PI, structural bioinformatics, Lund University) and Pontus Gourdon (co-PI, cryo-EM, Lund University and University of Copenhagen). This position is part of an ongoing large-scale research programme supported by the Knut and Alice Wallenberg Foundation, Göran Gustafsson Foundation and the Swedish Research Council.
Mets et al. Cell Host Microbe 2024
Ernits et al. 2023
Zhang et al. Nature 2022
Kurata et al. Mol. Cell 2021
Location: Lund, Sweden
Organisation: Lund University, Department of Experimental Medical Science
Links
AMBER call in EURAXESS main call (starting point for application)
Vasily Hauryliuk's profile in Lund University Research portal
Department of Molecular Enzymology's profile in Lund University Research portal