Trevor Forsyth
Principal Investigator
Professor Trevor Forsyth leads the Molecular Biophysics research group in the Medical Faculty at Lund University. The main research interests of his group concern the study of macromolecular systems using physical techniques such as neutron and X-ray scattering and other biophysical techniques including cryo electron microscopy.
Project in third call:
The structural basis of transthyretin amyloidosis and significance for amyloid cardiomyopathy
Principal Investigator
Professor Trevor Forsyth leads the Molecular Biophysics research group in the Medical Faculty at Lund University. The main research interests of his group concern the study of macromolecular systems using physical techniques such as neutron and X-ray scattering and other biophysical techniques including cryo electron microscopy.
Project in third call:
The structural basis of transthyretin amyloidosis and significance for amyloid cardiomyopathy
Principal Investigator
Professor Trevor Forsyth leads the Molecular Biophysics research group in the Medical Faculty at Lund University. The main research interests of his group concern the study of macromolecular systems using physical techniques such as neutron and X-ray scattering and other biophysical techniques including cryo electron microscopy.
Project in third call:
The structural basis of transthyretin amyloidosis and significance for amyloid cardiomyopathy
Short Biography
In 2021, Trevor Forsyth joined Lund University as Professor of Molecular Biophysics at the Faculty of Medicine and as the new Director of LINXS Institute of advanced Neutron and X-ray Science. Prior to this he was Head of the Life Sciences group at Institut Laue-Langevin in Grenoble (2000–2021), as well as Professor of Biophysics at Keele University in the United Kingdom.
His Molecular Biophysics Group have a particular interest in the molecular aspects of amyloid formation and the relationship to clinical manifestation in different types of amyloidosis such as transthyretin cardiomyopathy and polyneuropathy.
AMBER postdoctoral fellowship subject (Third call)
Amyloid cardiomyopathy – the structural basis of transthyretin amyloidosis
A highly motivated postdoctoral researcher is sought to work on the molecular mechanisms underlying amyloid formation and the associated assembly processes. The work will be based in the Molecular Biophysics Group within the Biomedical Center (BMC) at the Faculty of Medicine at Lund University, led by Professor Trevor Forsyth. The focus of the work will be transthyretin amyloidosis (see www.nature.com/articles/s41467-019-08609-z/). Human transthyretin (TTR) is protein that transports thyroxine and retinol-binding protein (RBP) in the serum and cerebrospinal fluid. Wild-type TTR is intrinsically amyloidogenic, but a large number of TTR mutants have been identified, having remarkable tissue specificities. This project seeks to deepen molecular-level understanding of amyloidosis as well and will involve detailed comparative studies of amyloid material derived from in vitro and ex vivo sources. It will make extensive use of X-ray and neutron diffraction, cryo-EM, and a wide range of other biophysical techniques, using the MAX-IV and ESS facilities in Sweden as well as the ESRF and ILL X-ray/neutron sources in Grenoble, France. The project will have good access to state-of-the-art facilities within the medical, natural science and engineering faculties, as well as being located in close proximity to the nearby MAX-IV synchrotron and ESS neutron beam facilities.
Location: Lund, Sweden
Organisation: Lund University, Faculty of Medicine, Department of Experimental Medical Science, Molecular Biophysics
Links
AMBER call in EURAXESS main call (starting point for application)
Trevor Forsyth's profile in Lund University Research portal
Unit of Molecular Biophysics's profile in Lund University Research portal