Remigiusz Serwa
Principal Investigator
Dr Remigiusz Serwa is core facility leader of the Proteomic Core Facility (PCF) at IMol, the institute of Polish Academy of Sciences.
Project in first call:
Functional alterations of protein import into mitochondria
Principal Investigator
Dr Remigiusz Serwa is core facility leader of the Proteomic Core Facility (PCF) at IMol, the institute of Polish Academy of Sciences.
Project in first call:
Functional alterations of protein import into mitochondria
Principal Investigator
Dr Remigiusz Serwa is core facility leader of the Proteomic Core Facility (PCF) at IMol, the institute of Polish Academy of Sciences.
Project in first call:
Functional alterations of protein import into mitochondria
Short Biography
Dr Remigiusz Serwa is the facility leader of The Proteomic Core Facility (PCF), which is a specialized laboratory dedicated to the analysis of complex mixtures of peptides and proteins. The research conducted at the laboratory mainly concern development of new chemoproteomic approaches for the interrogation of interactions between small molecules (e.g. metabolites, co-factors, post-translational modifiers, natural products, approved medicines, drug candidates) and proteins in living cells, whole organisms, or disease model systems.
AMBER postdoctoral fellowship subject (first call)
Functional alterations of protein import into mitochondria
Principal Investigators: Dr. Remigiusz Serwa and Prof. Agnieszka Chacinska; IMol Polish Academy of Sciences, Warsaw, Poland
Mitochondria are important biochemical and metabolic hubs of the cell. To perform their function, mitochondria need more than a thousand of proteins. Nearly all of them are synthesized in the cytosol and must be imported into a proper destination inside these organelles. Thus, understanding the quality control, as well as alterations in protein transport, is critical to understand the physiology and molecular basis of multiple pathologies derived from mitochondria. The project aims to dissect the function of two different variants of the complex inner membrane protein translocase called TIM23. Two variants which are defined by one of the forms of a key component TIM17 are differentially regulated. This regulation likely serves to achieve quality control of protein translocation across the inner mitochondrial membrane. The project aims to address the functional and architectural differences between two isoforms of TIM23, as well as the quality control at the level of inner mitochondrial membrane transport. The project is planned to accommodate a portfolio of cell and molecular biology methods complementing advanced proteomics approaches. The combination of technologies and expertise will allow to dissect the role and accuracy of protein import into and across the inner mitochondrial membrane, and functional implications of alterations in this key cellular process.
Location: Warsaw, Poland
Organisation: IMOL, Laboratory of Mitochondrial Biogenesis
Links
AMBER call in EURAXESS main call (starting point for application)
The International Institute of Molecular Mechanisms and Machines Polish Academy of Sciences